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Next oral administration of radiolabeled zafirlukast to volunteers, urinary excretion accounts for approximately 10% in the dose and the rest is excreted in feces. Zafirlukast isn't detected in urine.Zafirlukast is extensively hepatically metabolized by an enzyme identified as CYP2C9. Zafirlukast inhibits the action of CYP3A4, resulting in drug-dru